Genetic Variation in Alpha 2 - Adrenoreceptors and 1 Heart Rate Recovery after Exercise
نویسندگان
چکیده
3 Utkarsh Kohli, M.D., André Diedrich, M.D., Ph.D., Prince J. Kannankeril, M.D., 4 Mordechai Muszkat, M.D., Gbenga G. Sofowora, M.D., Maureen K. Hahn, 5 Ph.D., Brett A. English, Pharm.D., Ph.D., Randy D. Blakely, Ph.D., C. Michael 6 Stein, M.D., Daniel Kurnik, M.D. 7 8 Departments of Medicine, Pharmacology, Psychiatry, Biomedical Engineering and 9 Pediatrics, Divisions of Clinical Pharmacology and Genetic Medicine, and Centre for 10 Molecular Neuroscience, Vanderbilt University, Nashville, TN, Parexel International 11 Early Phase, Glendale, CA and Clinical Pharmacology Unit, Section of Clinical 12 Pharmacology and Toxicology, Rambam Health Care Campus, Haifa, Israel. 13 14 Address for correspondence: Daniel Kurnik, MD, Division of Clinical Pharmacology, 15 542 RRB, Vanderbilt University School of Medicine, Nashville, TN 37232, Tel: (615) 16 936-3420, Fax: (615) 936-2746, E-mail: [email protected] 17 Running title: Heart rate recovery and AR gene variants. 18 19 Articles in PresS. Physiol Genomics (June 9, 2015). doi:10.1152/physiolgenomics.00124.2014
منابع مشابه
Genetic variation in alpha2-adrenoreceptors and heart rate recovery after exercise.
Heart rate recovery (HRR) after exercise is an independent predictor of adverse cardiovascular outcomes. HRR is mediated by both parasympathetic reactivation and sympathetic withdrawal and is highly heritable. We examined whether common genetic variants in adrenergic and cholinergic receptors and transporters affect HRR. In our study 126 healthy subjects (66 Caucasians, 56 African Americans) pe...
متن کاملتاثیر تمرین ورزشی تناوبی بر ضربان قلب دوره ریکاوری و تغیرپذیری ضربان قلب افراد پس از عمل بای پس شریان کرونر
Abstract: Background: Hear rate turbulence, Disturbances in Vagal activity and reduced heart rate variability (HRV) is observed in individuals after coronary artery bypass grafting. Exercise training is recommended to improve these failures. Therefore, the aim of this study was to investigate the effects of interval exercise training on heart rate recovery (HRR) and heart rate variability af...
متن کاملVariability in heart rate recovery measurements over 1 year in healthy, middle-aged adults.
This study assessed the longer-term (12-month) variability in post-exercise heart rate recovery following a submaximal exercise test. Longitudinal data was analysed for 97 healthy middle-aged adults (74 male, 23 female) from 2 occasions, 12 months apart. Participants were retrospectively selected if they had stable physical activity habits, submaximal treadmill fitness and anthropometric measur...
متن کاملتأثیر تمرین هوازی در خشکی، آب معمولی و آب گرم بر تغییرپذیری ضربان قلب دوره ریکاوری در مردان جوان سالم
Background & Aims: The purpose of this study was to investigate the effects of land, warm and normal water aerobic exercises on heart rate variability in recovery period on healthy young men. Materials & Methods: In this study, subjects were randomly divided into four groups (control, Land aerobic exercise, normal water aerobic exercise, and warm water aerobic exercise) and performed reg...
متن کاملVariation in heart rate during submaximal exercise: implications for monitoring training.
A change in heart rate at a controlled submaximal exercise intensity is used as a marker of training status. However, the standard error of measurement has not been studied systematically, and therefore a change in heart rate, which can be considered relevant, has not been determined. Forty-four subjects (26.5 +/- 5.4 years; mean +/- standard deviation) participated in a submaximal running test...
متن کامل